If you have rheumatoid arthritis, your immune system mistakenly sends antibodies to the lining of your joints, where they attack the tissue surrounding the joint. This causes the thin layer of cells (synovium) covering your joints to become sore and inflamed, releasing chemicals that damage nearby cartilege and bones. patients complaining of severe swollen joints pain , morning stiffness, most commonly occurs in female . later on deformity of hand as well as other joints.